Interpret Your Estradiol (E2) Results
Enter your E2 value below and get an instant, free AI interpretation — a plain-English explanation checked against WHO/IFCC reference ranges.
Medical Disclaimer
This AI-generated interpretation is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Results may vary based on individual health factors not captured here.
Always consult a qualified healthcare professional before making any health decisions. Read full disclaimer →
Estradiol (E2) Normal Ranges
Estradiol (E2) is the most potent and predominant form of estrogen in reproductive-age women, produced primarily by ovarian follicles.
| Age Group | Sex | Reference Range | Unit | Notes |
|---|---|---|---|---|
| Adults (18–64) | Female | 30 – 400 | pg/mL | Follicular phase |
| Adults (18–64) | Female | 0 – 30 | pg/mL | Post-menopause |
| Adults (18–64) | Male | 10 – 50 | pg/mL | — |
Also reported in: pmol/L.
Why Doctors Order the Estradiol (E2) Test
Estradiol is essential in fertility evaluation — measuring it alongside FSH on cycle day 2–3 helps assess ovarian reserve and IVF response potential. Low estradiol causes hot flashes, bone loss, and vaginal atrophy (menopause or premature ovarian insufficiency).
How to Enter Your E2 Result
Estradiol (E2) can be reported in pg/mL or pmol/L. Choose the unit printed next to your result on the lab report so it is compared with the matching reference range.
Reference ranges for E2 differ between men and women, so entering your sex gives a more accurate reading.
What a Low or High E2 Can Be Associated With
Below the reference range
- Menopause (natural or surgical)
- Premature ovarian insufficiency (POI)
- Hypothalamic amenorrhea (exercise, eating disorders, stress)
- Hypopituitarism
- Turner syndrome
Above the reference range
- Ovarian follicular cysts
- Ovarian stimulation during IVF
- Obesity (peripheral aromatization of testosterone to estradiol)
- Estrogen-secreting ovarian tumors
- Cirrhosis (impaired estrogen metabolism)
These are common associations, not a diagnosis. A single result is read alongside your symptoms, history and other tests — discuss it with your doctor.
What Can Change Your E2 Result
Before you read too much into a result, consider whether any of these applied:
- Cycle phase (estradiol peaks dramatically at ovulation)
- Exogenous estrogen (oral contraceptives, HRT)
- Biotin supplements (can interfere with immunoassay)
- Obesity (higher baseline estradiol from peripheral aromatization)
Preparing for the test: In women, document the day of the menstrual cycle when the test is drawn — values vary markedly throughout the cycle. No fasting required.
Symptoms That Often Prompt E2 Testing
- Low estradiol: hot flashes, night sweats, vaginal dryness, bone loss, mood changes
- High estradiol in women: usually few symptoms; breast tenderness
- High estradiol in men: gynecomastia (enlarged breast tissue), reduced sperm count, erectile dysfunction
Want the full clinical guide to Estradiol (E2)?
Reference ranges, causes, symptoms, preparation, and FAQs.